CBD Gold Blog — endocannabinoid system


Another perspective of cannabidiol - aromatherapy 0

CBD is one of the main therapeutic agents that helps treat one of the many symptoms/ diseases, like epilepsy, that are traditionally harder to treat with any current medicines. The other symptoms/ diseases also include rheumatoid arthritis, diabetes, PTSD (Posttraumatic Stress Disorder), schizophrenia, neuropathic pain, seizures, convulsions and the list goes on. 

Since aromatherapy uses aromatic plant extracts and essential oils for healing purposes, it was only a matter of time before the health practitioners took a shine on CBD.

As we know, the fragrant essence of plants, including cannabis, comes from naturally occurring molecules, called terpenes. Terpenes are the main component of any plant resin or essential oils and play many important roles in the plant kingdom- from deterring insect predation, protection from environmental stresses and vitally, as chemical building blocks for more complex molecules, like cannabinoids, certain hormones, vitamins (Vitamin A), pigments and sterols.

Essential oils used in conventional aromatherapy derive from the extraction of these terpenes and their infusion into oils.

We are all familiar with cannabis as medicine or as a recreational drug, but the more subtle aspect of it being an aromatic plant goes too often unsaid. The herbs we use in our kitchen are considered aromatic plants because they contain a particular terpene profile that gives a distinctive flavor. Cannabis is so complex from this point of view that the possible terpene combinations are endless, creating a broad spectrum of aromas and flavors.

The diverse palate of cannabis flavors is impressive enough, but arguably the most fascinating characteristic of terpenes is their ability to interact synergistically with other compounds in the plant, like cannabinoids. This synergy has a scientific basis in our body’s endocannabinoid system. As we already know, CBD stimulates activity in ECS receptors (CB1 and CB2) without actually binding to them. This results in changes within any cells that contain either receptor. Because CB1 and CB2 receptors are present throughout the body, the effects of CBD are systemic.

Let's have a look at the video from Medical Cannabis Clinic Australia  perfectly explaining CBD's effects on the Endocannabinoid system:




CBD (Cannabidiol) studies around the world part 1 0

Cannabidiol (or its more common name 'CBD') has been attracting a great deal of attention recently.

CBD has shown nutritional potential for years, yet the taboo surrounding Cannabis has kept CBD well off the radar.

Now, that hemp has gained the reputation it deserves, it looks as though this little compound is finally poised for big market growth.

Let's look into the latest CBD research! 

Cannabidiol Anxiety Research

There have been many studies revering CBD to be an effective solution to anxiety , other studies promote its anti inflammatory qualities and there is even further studies proclaiming the potential for CBD as a powerful solution to epilepsy.

However, despite the early stage of many studies (some which are still very much at the pre-clinical stage), many doctors and medical organizations are already endorsing Cannabidiol as a low-risk treatment for anxiety, as well as exploring the possibilities of using CBD for more severe mood disorders closely related to anxiety, such as depression. 

Cannabidiol Antipsychotic Research

A preliminary clinical trial at the University of California–Irvine has concluded that CBD seems to treat schizophrenia as effectively as current antipsychotic medications, with far fewer side effects and at a lesser cost. Daniele Piomelli, a professor of pharmacology at the university and co-author of the study said, “The results were amazing, not only was [CBD] as effective as standard antipsychotics, but it was also essentially free of the typical side effects seen with antipsychotic drugs.”

Common side effects of antipsychotic drugs include social withdrawal, lack of motivation, and anxiety, all of which frequently occur in schizophrenia as well. Therefore, since those drugs can themselves cause some of schizophrenia’s symptoms, it is still unclear whether CBD is better at treating them or whether it is simply causing fewer of these side effects in the first place. This is the focus of many current studies on CBD’s properties.

Perhaps most interesting of all is the fact that CBD seems to counteract the psychotropic effects of THC, which has been shown to have strong correlation with psychosis when used long-term. Using CBD alongside THC seems to drastically lower the potential of the latter to cause psychosis, a fact that has taken many scientific teams by surprise.

Cannabidiol Arthritis Research 

Studies conducted in lab rats have shown that CBD drastically reduces a model of acute arthritis that applies to numerous different types of joint disorders. While these studies imply that CBD may only indirectly affect arthritis, the findings themselves are encouraging. Nonetheless, the exact mechanisms with which Cannabidiol interacts with arthritis are still not fully understood.

One other indirect benefit that CBD seems to have when administered for arthritis is that it has been shown to reduce the pain caused by several types of arthritis, including the prevalent rheumatoid arthritis. Still, it is not yet clear whether CBD’s anti-inflammatory properties or its analgesic effects play the biggest part in alleviating arthritis-induced pain. Some studies point toward both and if that is eventually proven, it may render CBD a widely accepted treatment for both arthritis and a host of arthritis-related pains.

The Endocannabinoid system and how it works 0

For the precise interpretation of cannabidiol (CBD) properties, you have to understand how does the Endocannabinoid system affect our brain. It's incredible that people have used cannabis for centuries as a natural medicine, but only in the past few decades have scientists truly understood how it works! 

What led to this understanding was the discovery of the endocannabinoid system; a unique biological system that facilitates the effects of marijuana within the human body.

What is the Endocannabinoid system?

The endogenous cannabinoid system (ECS), named after the plant that led to its discovery, is perhaps the most important physiologic system involved in establishing and maintaining human health. Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. 

While cannabinoid receptors (research has shown that  there are two types of cannabinoid receptors: CB1 and CB2) are primarily expressed in the brain and immune system, they can also be identified in a variety of other places as well, including the peripheral nervous system, cardiovascular system, reproductive system, and gastrointestinal and urinary tracts. Cannabinoid receptors continue to be identified in unique parts of the body as research on the endocannabinoid system progresses. 

What does it do?

Interestingly, the endocannabinoid system is not unique to the human species. Rather, research has shown that this system is common to all humans and vertebrate animals – and even some invertebrate animals – suggesting its significance in the process of evolution. Experts believe that natural selection has conserved the endocannabinoid system in living organisms for 500 million years.

Although the endocannabinoid system affects a wide variety of biological processes (such as appetite and sleep), experts believe that its overall function is to regulate homeostasis.

Homeostasis is a key element in the biology of all living things and is best described as the ability to maintain stable internal conditions that are necessary for survival. Disease is simply a result of some aspect of failure in achieving homeostasis, making the endocannabinoid system a unique target for medical applications.